The 26th International Symposium on Microsomes and Drug Oxidations

This oral presentation highlights the use of human microphysiological systems (MPS) to evaluate the efficacy, absorption, distribution, metabolism, and excretion (ADME), as well as the toxicity of antisense oligonucleotide (ASO) and small interfering RNA (siRNA) therapeutics. The talk will discuss how advanced MPS models better recapitulate human physiology compared with conventional in vitro systems, enabling more predictive assessment of on-target activity, biodistribution, metabolic stability, and organ-specific toxicities. By integrating MPS into the drug development pipeline, these platforms offer a powerful approach to improve translational accuracy and reduce late-stage attrition of RNA-based therapeutics.